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  • Title: Abnormal red cell membrane phosphatase activity in an unidentified congenital hemolytic anemia.
    Author: Delaunay J, Fischer S, Piau JP, Tortolero M, Manassero J, Schapira G.
    Journal: Biomedicine; 1979 Apr; 31(2):43-5. PubMed ID: 224968.
    Abstract:
    The erythrocyte membrane contains a neutral phosphatase, which was studied with p-nitrophenyl-phosphate as the substrate. The enzyme was investigated in four members of the same family, suffering from a congenital spherocytic hemolytic anemia. Although the condition was transmitted as a dominant trait, it was not identified to the common hereditary spherocytosis. The phosphatase, instead of having a Michaelis-Menten kinetics, displayed a dramatically biphasic kinetics: substrate excess generated partial inhibition of the enzyme. We consider that such an abnormality, which was never encountered before, is a distinctive feature of a given type of congenital hemolytic anemia.
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