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  • Title: Synthesis and potent in vitro activity of novel 1H-benzimidazoles as anti-MRSA agents.
    Author: Karataş H, Alp M, Yildiz S, Göker H.
    Journal: Chem Biol Drug Des; 2012 Aug; 80(2):237-44. PubMed ID: 22497759.
    Abstract:
    A new class of 1H-benzimidazolecarboxamidines was synthesized and evaluated for in vitro antibacterial and antifungal activities, including drug-resistant bacterial strains. The most potent compound (32) has the same ratio of anti-MRSA activity as Vancomycin (minimal inhibitory concentrations value 0.78 μg/mL). The mechanism of action for 1H-benzimidazolecarboxamidine appears to be different from existing antibacterial agents. These compounds have potential for development as a new class of potent anti-MRSA agent.
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