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  • Title: Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease.
    Author: Payão SL, Gonçalves GM, de Labio RW, Horiguchi L, Mizumoto I, Rasmussen LT, de Souza Pinhel MA, Silva Souza DR, Bechara MD, Chen E, Mazzotti DR, Ferreira Bertolucci PH, Cardoso Smith Mde A.
    Journal: J Neuroimmunol; 2012 Jun 15; 247(1-2):59-62. PubMed ID: 22498095.
    Abstract:
    Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.
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