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  • Title: Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol.
    Author: Hod M, Star S, Passonneau J, Unterman TG, Freinkel N.
    Journal: Isr J Med Sci; 1990 Oct; 26(10):541-4. PubMed ID: 2249926.
    Abstract:
    Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue myo-inositol following culture from day 9.5 to 11.5 of development in the presence of increased amounts of glucose. Reductions of myo-inositol and increased malformations are not corrected by aldose reductase inhibitors. In contrast, supplementation of culture medium with myo-inositol (1.5 mg/ml) restores tissue myo-inositol content, lowers the incidence of dysmorphogenic embryos (from 51.1 to 28.6%, P less than 0.001) and reduces the incidence of neural tube defects to control levels (from 33.3 to 6%, P less than 0.001). These results suggest that myo-inositol depletion is involved in the mechanism of diabetic embryopathy.
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