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  • Title: [Molecular test Genotype® MTBDRplus, an alternative to rapid detection of multidrug resistance tuberculosis].
    Author: Asencios L, Galarza M, Quispe N, Vásquez L, Leo E, Valencia E, Ramírez J, Acurio M, Salazar R, Mendoza-Ticona A, Cáceres O.
    Journal: Rev Peru Med Exp Salud Publica; 2012 Mar; 29(1):92-8. PubMed ID: 22510913.
    Abstract:
    The Genotype®MTBDRplus molecular test is a method that allows identification of the most frequent mutations associated with resistance to major first-line antituberculosis drugs, Isoniazid (INH) and Rifampicin (RFP). The aim of this study was to evaluate the performance of the molecular test with culture and smear- positive sputum samples. We evaluated 95 cultures and 100 sputum samples with resistance profiles previously determined by the reference method "Agar Plate Proportions" (APP). The molecular test from cultures showed a sensitivity of 100 %, 97,5 % and 96,97 % for RIF, INH and MDR respectively while from sputums the sensitivity was 95,65 %, 96,77 % and 95,24 % for RIF, INH and MDR respectively. We conclude that the molecular test Genotype®MTBDRplus is a very useful tool to detect resistance to isoniazid and rifampicin simultaneously (MDR-TB) in up to 72 hours from sputum samples or cultures.
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