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  • Title: [Changes in protein metabolism and the free amino acid profile in bladder cancer].
    Author: Nechiporenko NA, Nefedov LI, Klimovich II.
    Journal: Vopr Onkol; 1990; 36(10):1201-5. PubMed ID: 2251814.
    Abstract:
    Protein metabolism status was assessed by standard procedures versus tumor stage and nitrogen-excreting function of the kidneys in 250 cases of urinary bladder cancer. In addition, 18 amino acids in the blood were assayed in 63 patients. Standard methods of examination identified protein metabolism disturbances in patients with stage III-IV renal failure whereas amino acid profile showed changes at a much earlier stage. Patients with T3-4 tumors revealed decreased blood amino acid levels. Renal failure and surgical trauma caused the level of most amino acids checked to decrease. The need for correction of the amino acid profile of the blood before and after surgery is discussed.
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