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  • Title: Keratoacanthoma: clinical and histopathologic features of regression.
    Author: Ko CJ, McNiff JM, Bosenberg M, Choate KA.
    Journal: J Am Acad Dermatol; 2012 Nov; 67(5):1008-12. PubMed ID: 22521202.
    Abstract:
    BACKGROUND: The clinical and histopathologic features of regressing keratoacanthomas have not been adequately described in the literature. OBJECTIVE: "True" keratoacanthomas (ie, squamous tumors with evidence of spontaneous resolution) were studied clinically and histopathologically. METHODS: Nineteen crateriform tumors with a partial biopsy histopathologically compatible with keratoacanthoma were followed over time for correlation with biologic behavior (ie, regression). Tumors displaying spontaneous resolution, arbitrarily defined as a decrease in size of at least 25%, were categorized as keratoacanthomas. RESULTS: Seven regressing keratoacanthomas tended to show flattening before a decrease in diameter. Histopathologically, there was variable epidermal hyperplasia with generally prominent hyperkeratosis, retained crateriform architecture, and dermal fibrosis. LIMITATIONS: This study has a small sample size. CONCLUSIONS: Regressing keratoacanthomas show persistent crateriform architecture, clinically and histopathologically. Lesions become flatter before decreasing in diameter, and keratinocytes appear banal and lack glassy pink cytoplasm during regression.
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