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  • Title: Effects of culture supernatant from Lactobacillus pentosus strain S-PT84 on autonomic nerve activity in rats.
    Author: Beppu Y, Izumo T, Horii Y, Shen J, Fujisaki Y, Nakashima T, Tsuruoka N, Nagai K.
    Journal: In Vivo; 2012; 26(3):355-9. PubMed ID: 22523286.
    Abstract:
    Intestinal administration of various lactobacilli has been reported to affect autonomic neurotransmission, blood pressure, blood glucose, and body weight in rats, however, the mechanisms of action of the lactobacilli remain to be clarified. Therefore, the effect of the culture supernatant of Lactobacillus pentosus strain S-PT84 on the autonomic nerve activity in urethane-anesthetized rats was investigated. Intraduodenal injection of the low-molecular-weight (LMW) fraction (molecules less than 10,000 Da) of the S-PT84 culture supernatant elevated the brown adipose tissue sympathetic nerve activity and reduced the gastric vagal nerve activity. Moreover, intraoral administration of this LMW fraction increased the body temperature of rats above the interscapular brown adipose tissue. These results suggest that the LMW fraction of the S-PT84 culture supernatant affects the autonomic nerve activity and thermogenesis, and that the change in thermogenesis may be caused by the change in the sympathetic nerve activity of brown adipose tissue.
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