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  • Title: Access to spirocyclic oxindoles via N-heterocyclic carbene-catalyzed reactions of enals and oxindole-derived α,β-unsaturated imines.
    Author: Jiang K, Tiwari B, Chi YR.
    Journal: Org Lett; 2012 May 04; 14(9):2382-5. PubMed ID: 22524534.
    Abstract:
    A diastereoselective access to β-lactam fused spirocyclic oxindoles and related compounds bearing all carbon spiro centers is described. This N-heterocyclic carbene-catalyzed process employed challenging β,β-disubstituted α,β-unsaturated imines to react with enals.
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