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  • Title: Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering.
    Author: Langkilde AE, Vestergaard B.
    Journal: Methods Mol Biol; 2012; 849():137-55. PubMed ID: 22528088.
    Abstract:
    Structural investigation of the species present during protein fibrillation is of tremendous importance, yet complicated by the equilibrium between species of very different sizes and life-times. Small-angle X-ray scattering may be applied to solve this problem, providing both information about the process (number of species present and volume fractions of individual species) and low-resolution three-dimensional shape reconstructions of individual species. Here, we describe in detail the challenges associated with the approach, exemplified using data from fibrillating insulin or α-synuclein samples.
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