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  • Title: Study of neurotoxic intracellular calcium signalling triggered by amyloids.
    Author: Villalobos C, Caballero E, Sanz-Blasco S, Núñez L.
    Journal: Methods Mol Biol; 2012; 849():289-302. PubMed ID: 22528098.
    Abstract:
    Neurotoxicity in Alzheimer's disease (AD) is associated to dishomeostasis of intracellular Ca(2+) induced by amyloid β peptide (Aβ) species. Understanding of the effects of Aβ on intracellular Ca(2+) homeostasis requires preparation of the different Aβ assemblies including oligomers and fibrils and the testing of their effects on cytosolic and mitochondrial Ca(2+) in neurons. Procedures for cerebellar granule cell culture, preparation of Aβ species as well as fluorescence and bioluminescence imaging of cytosolic and mitochondrial Ca(2+) in neurons are described.
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