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  • Title: Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.
    Author: Martin DP, Cohen SM.
    Journal: Chem Commun (Camb); 2012 May 28; 48(43):5259-61. PubMed ID: 22531842.
    Abstract:
    A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.
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