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  • Title: Plasma and urinary growth hormone and insulin-like growth factor I in children with chronic renal insufficiency.
    Author: Perrone L, Sinisi AA, Criscuolo T, Manzo T, Maresca G, Bellastella A, del Gado R.
    Journal: Child Nephrol Urol; 1990; 10(2):72-5. PubMed ID: 2253254.
    Abstract:
    We investigated the plasma and urinary growth hormone (GH) levels, and plasma insulin-like growth factor (IGF-I) in 15 (8 prepubertal and 7 pubertal) subjects with chronic renal insufficiency. Four of our 7 pubertal patients had a short stature (standard deviation score from -2.7 to -4.0). Significantly increased plasma GH and IGF-I levels were found in pubertal subjects alone (p less than 0.05). The urinary GH levels was significantly increased in prepubertal and pubertal subjects (p less than 0.001 and 0.05, respectively). A significantly inverse correlation between urinary GH excretion and creatinine clearance was found (r = -0.55; p less than 0.05). Increased plasma GH, IGF-I and urinary GH levels seem to suggest a complex alteration of GH and somatomedin metabolism in central and peripheral (receptor) cells.
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