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  • Title: Penetration of aminoglycosides into human peritoneal tissue.
    Author: Serour F, Dan M, Gorea A, Gilad A, Krispin M, Berger SA.
    Journal: Chemotherapy; 1990; 36(4):251-3. PubMed ID: 2253495.
    Abstract:
    Each of 30 patients underwent elective laparotomy following administration of a single intravenous dose of amikacin, netilmicin or tobramycin. Therapeutic concentrations of amikacin were achieved in peritoneal tissue in 10/10 patients. Only 13/20 samples from patients receiving the other two antibiotics showed antibacterial activity. Our data suggest that the penetrability of tobramycin (53%) and amikacin (39%) into the uninflamed peritoneal tissue is superior to that of netilmicin (16%).
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