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  • Title: Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
    Author: Kapas I, Majtenyi K, Törö K, Keller E, Voigtländer T, Kovacs GG.
    Journal: Metab Brain Dis; 2012 Jun; 27(2):231-5. PubMed ID: 22535301.
    Abstract:
    In the present study we evaluated cases referred as suspected Creutzfeldt-Jakob disease (CJD). Five out of 59 without prion disease showed neuropathological features of pellagra encephalopathy with widespread chromatolytic neurons (age range 40-48 years at death; one woman). These patients presented with a progressive neuropsychiatric disorder lasting for 2 to 24 months. Common symptoms included gait disorder, para- or tetraspasticity, extrapyramidal symptoms, incontinence, and myoclonus. Protein 14-3-3 in the cerebrospinal fluid was examined in a single patient and was positive, allowing the clinical classification as probable sporadic CJD. Pellagra encephalopathy may be considered as a differential diagnosis of CJD including detection of protein 14-3-3.
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