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  • Title: Stability testing of alginate-chitosan films.
    Author: Rabisková M, Dvorácková K, Kofronvá L.
    Journal: Ceska Slov Farm; 2012 Feb; 61(1-2):26-33. PubMed ID: 22536650.
    Abstract:
    Pellets containing rutin prepared by the extrusion/spheronization method were coated with sodium alginate-chitosan film. Important quality parameters in the pellets before coating were determined, and after coating the dissolution profiles of the drug were evaluated in dissolution media of the pH corresponding to the conditions in the gastrointestinal tract. Samples of coated pellets were located in the boxes for stability testing under different conditions, i.e. 25 degrees C and 60% of relative humidity (RH); 30 degrees C and 65% RH and 40 degrees C and 75% RH. After 1, 3, 6, 9 and 12 months (or 1, 3 and 6 months), the dissolution test was repeated and compared with the original profiles using similarity factors. All similarity factor values above 50 indicate excellent stability of alginate-chitosan films.
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