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  • Title: Developmental haemostasis for factor V and factor VIII levels in neonates: a case report of spontaneous cephalhaematoma.
    Author: Abdullah WZ, Ismail R, Nasir A, Mohamad N, Hassan R.
    Journal: Fetal Pediatr Pathol; 2013 Apr; 32(2):77-81. PubMed ID: 22536947.
    Abstract:
    Combined factor V and VIII deficiency is a rare bleeding disorder. Diagnosis of congenital coagulation factor deficiency in a neonate is challenging due to "immaturity" of the hemostatic system. A 2-day-old baby girl presented with spontaneous cephalhematoma. She was found to have persistent abnormal coagulation tests and finally diagnosed as combined factor V and VIII deficiency. Interestingly, factor V and factor VIII in developmental hemostasis are quite similar with adult levels in newborn, and hence early diagnosis is possible. An investigation to detect underlying hemostatic defects is recommended in newborns with spontaneous cephalhematoma.
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