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  • Title: Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues.
    Author: Huang P, Qiu J, You J, Hong J, Li B, Zhou K, Chen G, Yuan Y, Zou R.
    Journal: Biomarkers; 2012 Aug; 17(5):422-9. PubMed ID: 22537152.
    Abstract:
    OBJECTIVE: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC). METHODS: CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction. RESULTS: Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival. CONCLUSIONS: Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.
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