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  • Title: [The effect of the complex platinum (IV) compound oxoplatinum on the immune system].
    Author: Brin EV, Rytenko AN, Uteshev BS.
    Journal: Farmakol Toksikol; 1990; 53(5):52-4. PubMed ID: 2253752.
    Abstract:
    The effect of a Pt (IV) complex compound--oxoplatinum on the humoral and cell immunity in mice was studied. It was established that the drug produced dose-dependent inhibition of T-dependent humoral response to ram erythrocytes. Oxoplatinum appeared to be a costimulator of a mitogen phytohemagglutinin in lymphocyte proliferation slightly influencing allogen-induced proliferation. The stimulation of T-lymphocyte cytotoxicity by small doses of oxoplatinum was also found.
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