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  • Title: A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes).
    Author: Zhou W, Chen W, Wang L.
    Journal: Org Biomol Chem; 2012 Jun 07; 10(21):4172-8. PubMed ID: 22538559.
    Abstract:
    2-Cyanobenzofurans and 2-cyanobenzothiophenes were prepared through an efficient one-pot Ullmann-reaction/cyanation reaction. In the presence of CuI/Na(2)CO(3)-Pd(OAc)(2)/PPh(3) in DMF, the reaction of 2-(gem-dibromovinyl)phenols and 2-(gem-dibromovinyl)thiophenols with K(4)Fe(CN)(6), as non-toxic and user-friendly cyanating reagent, proceeded smoothly to generate the corresponding 2-cyanobenzofurans and 2-cyanobenzothiophenes in good yields.
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