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  • Title: [Monoclonal antibodies ICO-11 in the prognostic evaluation of acute nonlymphoblastic leukemia].
    Author: Tupitsyn NN, Volkova MA, Perilov AA, Artem'ev AK.
    Journal: Gematol Transfuziol; 1990 Aug; 35(8):7-9. PubMed ID: 2253864.
    Abstract:
    The antigen detectable with monoclonal antibodies ICO-11 was studied in cells of 33 patients with acute lymphoblastic leukemia (ALL) and 47 patients with acute non-lymphoblastic leukemia (ANLL). The incidence rate of antigen-positive cases in ALL comprised 39.4%, in ANLL 35.4%. The presence of antigen in blasts in ALL did not influence the disease prognosis. The presence of ICO-11+ blasts in ANLL was characteristic of the group of patients with more favourable prognosis: a higher survival rate, due to a higher frequency of remissions, a longer life-time in the absence of remission. Basing on the clinico-hematological data ICO-11+ group could not be identified as more favourable prognostically.
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