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  • Title: R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1).
    Author: Takahashi E, Hori T, O'Connell P, Leppert M, White R.
    Journal: Hum Genet; 1990 Nov; 86(1):14-6. PubMed ID: 2253935.
    Abstract:
    A new mapping system, based on nonisotopic in situ hybridization combined with fluorescent staining of replicated prometaphase R-bands, is described. Replication of the bands is achieved by treatment of thymidine-synchronized cells with bromodeoxyuridine. The human COL2A1 gene was mapped to band 12q13.11-q13.12 in this manner, to illustrate the potential of the technique for improving the precision of chromosomal mapping and physical ordering of genes.
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