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  • Title: Influence of parathyroidectomy on liver glycogen in rats treated with carbon tetrachloride.
    Author: Rastogi S, Rana SV.
    Journal: Indian J Exp Biol; 1990 Aug; 28(8):794-5. PubMed ID: 2253976.
    Abstract:
    Carbon tetrachloride (CCl4) brings about a rise in cytosolic free calcium which may lead to glycogen mobilization. Therefore, glycogen and glucose-6-phosphatase (G-6-pase) levels in the liver of parathyroidectomized (PTX) rats following CCl4 treatment have been estimated. CCl4 depletes both glycogen and G-6-pase levels in the liver. PTX followed by CCl4 administration, however, fails to restore liver glycogen and G-6-pase levels. The results suggest that neither cytosolic Ca2+ nor phospholipase A2 mediation is needed for glycogen mobilization, however, glucocorticoid intervention might have a role in such mechanisms.
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