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  • Title: Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles.
    Author: Yan W, Wang D, Feng J, Li P, Zhao D, Wang R.
    Journal: Org Lett; 2012 May 18; 14(10):2512-5. PubMed ID: 22540839.
    Abstract:
    A simple and general method in the synthesis of N-alkoxycarbonyl ketimines derived from isatins has been described first. Generally, the enantioselective addition of 1,3-dicarbonyl compounds to this kind of ketimine affords chiral 3-amino oxindoles in high yield and excellent ee.
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