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  • Title: Supramolecular polymers as dynamic multicomponent cellular uptake carriers.
    Author: Petkau-Milroy K, Sonntag MH, van Onzen AH, Brunsveld L.
    Journal: J Am Chem Soc; 2012 May 16; 134(19):8086-9. PubMed ID: 22540882.
    Abstract:
    Supramolecular synthesis represents a flexible approach to the generation of dynamic multicomponent materials with tunable properties. Here, cellular uptake systems based on dynamic supramolecular copolymers have been developed using a combination of differently functionalized discotic molecules. Discotics featuring peripheral amine functionalities that endow the supramolecular polymer with cellular uptake capabilities were readily synthesized. This enabled the uptake of otherwise cell-impermeable discotics via cotransport as a function of supramolecular coassembly. Dynamic multicomponent and multifunctional supramolecular polymers represent a novel and unique platform for modular cellular uptake systems.
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