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  • Title: Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain.
    Author: Guerrini K, Argo A, Borroni C, Catalano D, Dell'acqua L, Farè F, Procaccianti P, Roda G, Gambaro V.
    Journal: J Pharm Biomed Anal; 2013 Jan 25; 73():125-30. PubMed ID: 22541710.
    Abstract:
    Brain distribution pattern of "street" heroin metabolites (morphine and codeine) was investigated in two fatalities due to "acute narcotism". A suitable sample pretreatment prior to solid-phase-extraction was developed to achieve a good recovery of the analytes and to eliminate the interfering species. After derivatization with MSTFA, samples were analyzed by GC/MS. Specificity, accuracy, precision and linearity of the method were evaluated; LOD and LOQ were, respectively, 10ng/25ng for morphine and 5ng/10ng for codeine. This method was applied to the analysis of six brain areas (hippocampus, frontal lobe, occipital lobe, nuclei, bulb and pons) coming from two cases of heroin-related deaths. No evidence of accumulation of metabolites in a specific brain region was found.
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