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  • Title: n-Butanol partitioning and phase behavior in DPPC/DOPC membranes.
    Author: Kurniawan Y, Venkataramanan KP, Scholz C, Bothun GD.
    Journal: J Phys Chem B; 2012 May 24; 116(20):5919-24. PubMed ID: 22546177.
    Abstract:
    Membrane phase behavior and fluidization have been examined in heterogeneous membranes composed of dipalmitoylphosphatidylcholine (DPPC, a saturated lipid) and dioleoylphosphatidylcholine (DOPC, an unsaturated lipid) at n-butanol concentrations below and above the interdigitation threshold of DPPC. Our results show that the presence of DOPC did not influence the interdigitation concentration of n-butanol on DPPC (0.1-0.13 M) despite the fact that DOPC increased n-butanol partitioning into the membranes. When DPPC was the continuous phase, up to equimolar DPPC:DOPC, n-butanol partitioning into gel or interdigitated DPPC was only slightly affected by the presence of DOPC. In this case a "cooperative effect" of DOPC + n-butanol eliminated the DPPC pretransition phase and yielded an untilted gel-like phase. When DOPC was the continuous phase, more n-butanol was needed to cause DPPC interdigitation (0.2 M), which was attributed to n-butanol residing at the interface between DOPC and DPPC domains. To our knowledge, this is the first study to examine the effects of n-butanol partitioning on membranes composed of saturated and unsaturated lipids that exhibit coexisting phase states.
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