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  • Title: Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma.
    Author: Koivunen P, Bäck L, Pukkila M, Laranne J, Kinnunen I, Grénman R, Mäkitie AA.
    Journal: Laryngoscope; 2012 Aug; 122(8):1734-8. PubMed ID: 22549303.
    Abstract:
    OBJECTIVES/HYPOTHESIS: The first International Union Against Cancer (UICC) TNM classification for aerodigestive malignant mucosal melanoma was not published until 2009, and since then, only a few studies have evaluated the accuracy of this staging system. Our aim was to evaluate the accuracy of this UICC staging system for sinonasal malignant mucosal melanoma (SMMM) in a nationwide survey. STUDY DESIGN: Retrospective, population-based, multicenter study. METHODS: The hospital surgical and discharge registries were used to identify the patients. A database including demographic and clinicopathologic variable was created. RESULTS: Altogether, 50 SMMM patients diagnosed in Finland from 1990 to 2004 were evaluated. Three- and 5-year overall survival rates were 44% and 27%, respectively. Significant differences in overall survival according to T classification (P = .028, log rank) and stage (P = .02, log rank) were found. Tumor extension to the sphenoid sinus had a significant negative impact on survival (n = 11, P = .03, log rank). CONCLUSIONS: The current UICC staging system for mucosal melanoma provides a useful format for staging SMMMs in clinical settings.
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