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  • Title: Rituximab in a child with autoimmune thrombotic thrombocytopenic purpura refractory to plasma exchange.
    Author: Narayanan P, Jayaraman A, Rustagi RS, Mahadevan S, Parameswaran S.
    Journal: Int J Hematol; 2012 Jul; 96(1):122-4. PubMed ID: 22552883.
    Abstract:
    A nine-year-old girl presented with headache, purpura and mild left hemiparesis. Laboratory evaluation revealed thrombotic microangiopathy with ADAMTS13 deficiency, with auto-antibodies to ADAMTS13. She was treated with plasma exchange and steroids, following which she improved transiently, relapsing within 2 months. The relapse was refractory to conventional therapy and rituximab was tried. She had good response to rituximab and has been in remission for the past 12 months. Rituximab may be a promising option for children with acquired TTP refractory to plasma exchange and steroids.
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