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  • Title: Association between the CD209 promoter -336A/G polymorphism and susceptibility to tuberculosis: a meta-analysis.
    Author: Miao R, Li J, Sun Z, Li C, Xu F.
    Journal: Respirology; 2012 Jul; 17(5):847-53. PubMed ID: 22553928.
    Abstract:
    BACKGROUND AND OBJECTIVE: Dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional -336A/G polymorphism in the CD209 promoter region has been associated with susceptibility to tuberculosis (TB), but the results have been inconclusive. We performed a meta-analysis to clarify the relationship between the CD209-336A/G variant and the risk of TB. METHODS: Ten studies involving a total of 2598 TB patients and 2614 control subjects were systematically reviewed, and the data were quantitatively synthesized by meta-analysis. The Q-test was applied to assess the heterogeneity of associations among the studies, and Egger's regression test was used to assess potential publication bias. RESULTS: No significant association was identified between the CD209-336A/G polymorphism and risk of TB (G allele vs A allele: odds ratio (OR) 1.02, 95% confidence interval (CI) 0.90-1.15). Moreover, no significant association was observed in populations of African ethnicity (OR 1.01, 95% CI 0.87-1.17) or among individuals who were negative for the human immunodeficiency virus (OR 0.98, 95% CI 0.84-1.15). CONCLUSIONS: This meta-analysis has indicated that the CD209-336A/G polymorphism may not contribute to susceptibility to TB.
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