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  • Title: Antiprotozoal sesquiterpene pyridine alkaloids from Maytenus ilicifolia.
    Author: Santos VA, Regasini LO, Nogueira CR, Passerini GD, Martinez I, Bolzani VS, Graminha MA, Cicarelli RM, Furlan M.
    Journal: J Nat Prod; 2012 May 25; 75(5):991-5. PubMed ID: 22559947.
    Abstract:
    As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC(50) values of 1.4 and 41.9 μM, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC(50) of 1.8 mM).
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