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  • Title: [Changes in the histochemical composition of mucins in goblet cells in the course of a Nippostrongylus brasiliensis infection in the rat].
    Author: Koninkx JF, Mirck MH, Hendriks HG, Mouwen JM, van Dijk JE.
    Journal: Tijdschr Diergeneeskd; 1990 Nov 15; 115(22):1051-7. PubMed ID: 2256096.
    Abstract:
    Rats were infected with Nippostrongylus brasiliensis, and changes in the histochemical composition of mucins in jejunal goblet cells were investigated. Ten days after infection, mitotic activity was extensively in jejunal crypts: both crypts and villi were characterised by hyperplasia of goblet cells. Infected rats had a markedly greater number of crypt and villi goblet cells containing neutral mucin than the control rats did. Moreover, 15 days after infection, infected rats had significantly more goblet cells containing acid mucin than control rats did. In infected rats, the acid mucins in goblet cells (day 15) appeared to be predominantly sulphomucins, whereas in control rats the acid mucins were predominantly sialomucins. The experiments established that when N. brasiliensis is excreted by rats, the histochemical composition of mucins in crypt and villi goblet cells has been changed not only quantitatively, but also qualitatively.
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