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  • Title: [The antibody activity to synthetic C-terminal fragments of the heavy-chain hemagglutinins of influenza virus A subtypes H1 and H3].
    Author: Mazurkova NA, Kalashnikov VV, Mizenko GA, Samukov VV, Podcherniaeva RIa.
    Journal: Vopr Virusol; 1990; 35(4):283-6. PubMed ID: 2256311.
    Abstract:
    C-terminal peptide fragments of the heavy chain (HA1) of influenza virus, subtypes H1 and H3, hemagglutinins were synthesized. Rabbits and guinea pigs immunized with peptides H3 (314-328) and H1 (314-328) conjugates with BSA developed high immune response to conjugated peptides. Solid-phase RIA demonstrated interaction of antisera to peptide H3 (314-328) with A/Aichi/2/68 virus which was inhibited by peptides H3 (314-328) and H3 (317-328) but not by H3 (320-328), that is, antibodies interacted predominantly with amino acids 317-323 HA1. Anti-H3 (314-328)-BSA showed a marked activity in H1 and NT with a number of H3 subtype viruses. Antisera to peptide H1 (314-328) reacted with A/PR/8/34 virus insignificantly and were also inactive in H1 and NT with subtype H1 viruses.
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