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  • Title: Protective role of Shenfu on ischemia-reperfusion injury of rat liver grafts.
    Author: Chen T, Cheng M, Yuan Z, Zhou S, Yu Z.
    Journal: Transplant Proc; 2012 May; 44(4):978-81. PubMed ID: 22564601.
    Abstract:
    AIMS: We sought to investigate the protective role of Shenfu (SF),a traditional Chinese formulation comprising Radix Ginseng and Radix Aconitum Carmichaeli on ischemia-reperfusion injury in rat liver grafts. METHODS: Ninety-six male Sprague Dawley rats were used as donors (n = 48) and recipients (n = 48) of orthotopic liver transplantation. They were randomly divided into a control group with donor livers injected with saline through the portal vein immediately after recovery versus the SF group, with livers injected with SF. Each group was further divided into 3 subgroups equally to obtain bood and hepatic tissues samples at 2, 4, and 6 hours reperfusion. RESULTS: At each phase, the SF group, showed significantly higher bile production (P < .05) with lower serum levels of alanine aminotransferase and tumor necrosis factor-α, and nuclear factor-κB expression in the hepatic tissues. (P < .05). SF group hepatic tissues showed less injury compared with controls. CONCLUSION: SF injection seemed to protect hepatocytes from injury during the early reperfusion phase and to improve subsequent rat liver graft function.
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