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  • Title: Glutathione-gated K+ channels of Escherichia coli carry out K+ efflux controlled by the redox state of the cell.
    Author: Meury J, Robin A.
    Journal: Arch Microbiol; 1990; 154(5):475-82. PubMed ID: 2256781.
    Abstract:
    The kinetics of K+ efflux across the membranes of i) wild-type Escherichia coli poisoned by the thiol reagent N-ethylmaleimide, ii) K+ retention mutants and iii) glutathione-deficient mutants, have revealed a common "K+ leaky phenotype"; it is characterized by a very high rate of K+ efflux. The results suggest that the products of kefB and kefC genes could encode two K+ channels, both gated by glutathione. The possible function of these K+ channels seems to be a K+ exit controlled by the redox state of the cell; indeed, it can be inferred from the effects of several oxidants and reductants that turning on and off of the K+ efflux mediated by the channels can be correlated with the redox state of glutathione.
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