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  • Title: Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392*.
    Author: Schulz D, Nachtigall J, Geisen U, Kalthoff H, Imhoff JF, Fiedler HP, Süssmuth RD.
    Journal: J Antibiot (Tokyo); 2012 Jul; 65(7):369-72. PubMed ID: 22569163.
    Abstract:
    Streptomycetes were isolated out of a soil sample taken from the rhizosphere of a spruce stand and screened by HPLC-diode array analysis for the production of secondary metabolites. This led to the detection of silvalactam, a novel 24-membered macrolactam antibiotic in extracts of Streptomyces strain Tü 6392. The structure was determined by MS and NMR spectroscopy experiments. Silvalactam shows a potent antiproliferative activity against various cancerous and non-cancerous cell lines.
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