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  • Title: Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K.
    Author: Yamada T, McGeer PL, Baimbridge KG, McGeer EG.
    Journal: Brain Res; 1990 Sep 03; 526(2):303-7. PubMed ID: 2257487.
    Abstract:
    The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single case of strionigral degeneration. CaBP-positive neurons were preferentially localized to the mediodorsal portion of the substantia nigra pars compacta (SNC) in the beta layer, while CaBP-negative, melanin-positive neurons were concentrated in the ventrolateral SNC in the alpha layer. In Parkinson's disease and the case of strionigral degeneration, there was a relative sparing of the CaBP-positive neurons compared with CaBP-negative, pigmented neurons. These data imply that CaBP may confer some protection to SNC dopaminergic neurons against the pathological process which is responsible for Parkinson's disease and strionigral degeneration.
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