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  • Title: Measurement of optic disc size and rim area with spectral-domain OCT and scanning laser ophthalmoscopy.
    Author: Moghimi S, Hosseini H, Riddle J, Lee GY, Bitrian E, Giaconi J, Caprioli J, Nouri-Mahdavi K.
    Journal: Invest Ophthalmol Vis Sci; 2012 Jul 09; 53(8):4519-30. PubMed ID: 22577077.
    Abstract:
    PURPOSE: To compare optic disc and neuroretinal rim area measurements from spectral-domain optical coherence tomography (SD-OCT) to those from confocal scanning laser ophthalmoscopy. METHODS: Seventy-one eyes from 43 normal subjects or suspected/definite glaucoma patients were prospectively enrolled. All subjects had biometry with the IOLMaster and disc/retinal nerve fiber layer imaging with Cirrus SD-OCT (Optic Disc Cube 200×200) and Heidelberg Retina Tomograph (HRT). Uncorrected disc and rim areas and measurements corrected for eye magnification with Bennett's formula (AL-corrected measurements), along with 30° sectoral rim areas, vertical cup-to-disc ratio (VCDR), and cup volume, were compared between the two devices. RESULTS: The median (range) axial length (AL) was 24.2 mm (22.4-27.7 mm). Mean keratometry-corrected HRT disc area measurements were larger than AL-corrected HRT and SD-OCT measurements (P < 0.001 for both) and the difference was a function of keratometry measurements (K-readings). The AL-corrected HRT disc area and uncorrected/corrected Cirrus disc areas were not significantly different (P > 0.481). HRT rim area was larger than Cirrus measurements (P < 0.001) and the difference decreased with decreasing rim area. HRT VCDR and cup volume were significantly smaller than Cirrus measurements (P < 0.001). The correlations for sectoral rim areas between the two devices were moderate at best (intraclass correlation coefficients = 0.12-0.65). CONCLUSIONS: HRT overestimated optic disc area as compared to SD-OCT. A portion of the difference in HRT and SD-OCT disc measurements is due to HRT's magnification correction algorithm. Rim area measurements from HRT were larger than from SD-OCT, likely a result of different definitions for the reference plane and differences in disc area measurements. Disc parameters from the two devices are not interchangeable.
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