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  • Title: [Obesity, body fat distribution and the incidence of breast, cervical, endometrial and ovarian carcinomas].
    Author: Sönnichsen AC, Lindlacher U, Richter WO, Schwandt P.
    Journal: Dtsch Med Wochenschr; 1990 Dec 14; 115(50):1906-10. PubMed ID: 2257779.
    Abstract:
    The connection of body fat distribution (BFD) and the risk of developing mammary, cervical, endometrial or ovarian carcinoma was ascertained for 163 patients with carcinoma (mean age 49.9 [19-78] years) and 489 controls of comparable age and body-mass index. BFD was expressed as the ratio of waist and hip circumference (T/H ratio of 0.822 vs 0.781 and 0.826 vs 0.789, respectively; P less than 0.01). In premenopausal women with mammary or cervical carcinoma and in all postmenopausal women BFD was similar to that in the control subjects. A common cause of android obesity and ovarian or endometrial carcinoma may be a reduction of sex-hormone-binding globulins with an elevated serum level of free androgens and oestrogens.
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