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  • Title: Inotropic effects of ranitidine.
    Author: Meyer EC, Sommers DK, van Wyk M, Avenant JC.
    Journal: Eur J Clin Pharmacol; 1990; 39(3):301-3. PubMed ID: 2257871.
    Abstract:
    The purpose of this controlled study was to study the effect of cimetidine and ranitidine on the myocardium of 8 healthy male volunteers using systolic time intervals. Ranitidine caused a significant decrease in the QS2I, as from 40 min indicating a positive inotropic effect. There were no significant changes in heart-rate or blood-pressure. It is postulated that ranitidine, differing structurally from cimetidine, may have a higher affinity for H2-presynaptic receptors at the sympathetic myocardial junction resulting in an increase in noradrenaline and an increased inotropic effect.
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