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  • Title: Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+.
    Author: Li Y, Li L, Pu X, Ma G, Wang E, Kong J, Liu Z, Liu Y.
    Journal: Bioorg Med Chem Lett; 2012 Jun 15; 22(12):4014-7. PubMed ID: 22579421.
    Abstract:
    A novel ratiometric fluorescent peptidyl chemosensor (Dansyl-Cys-Pro-Gly-Cys-Trp-NH(2), D-P5) for metal ions detection has been synthesized via Fmoc solid-phase peptide synthesis. The chemosensor exhibited a high selectivity for Cd(2+) over other metal ions including competitive transition and Group I and II metal ions in neutral pH. The fluorescence emission intensity of D-P5 was significantly enhanced in the presence of Cd(2+) by fluorescent resonance energy transfer (FRET) and chelation enhanced fluorescence (CHEF) effects. The binding stoichiometry, detection limit, binding affinity, reversibility and pH sensitivity of the sensor for Cd(2+) were investigated.
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