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  • Title: Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
    Author: Manase MJ, Mitaine-Offer AC, Pertuit D, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Mirjolet JF, Duchamp O, Lacaille-Dubois MA.
    Journal: Fitoterapia; 2012 Sep; 83(6):1115-9. PubMed ID: 22579841.
    Abstract:
    A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.
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