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  • Title: Zeolitic Imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle.
    Author: Sun CY, Qin C, Wang XL, Yang GS, Shao KZ, Lan YQ, Su ZM, Huang P, Wang CG, Wang EB.
    Journal: Dalton Trans; 2012 Jun 21; 41(23):6906-9. PubMed ID: 22580798.
    Abstract:
    Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.
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