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  • Title: Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease: the FADES risk score.
    Author: van Rees JB, Borleffs CJ, van Welsenes GH, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Schalij MJ.
    Journal: Heart; 2012 Jun; 98(11):872-7. PubMed ID: 22581736.
    Abstract:
    OBJECTIVES: To construct a risk score out of baseline variables to estimate the risk of death without prior implantable cardioverter defibrillator (ICD) in primary prevention ICD patients with ischaemic heart disease. DESIGN: Retrospective cohort study. SETTING: Tertiary care facility in The Netherlands. PATIENTS: All patients with ischaemic heart disease who received an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center, Leiden, The Netherlands in the period 1996-2009. MAIN OUTCOME MEASURE: All-cause mortality without prior appropriate ICD therapy (anti-tachycardia pacing or shock). RESULTS: 900 patients (87% men, mean age 64±10 years) were included in the analysis. During a median follow-up of 669 days (IQR 363-1322 days), 150 patients (17%) died and 191 (21%) patients received appropriate device therapy. 114 (13%) patients died without prior appropriate therapy. Stratification of the risk for death without prior appropriate therapy resulted in risk categorisation of patients as low, intermediate or high risk. NYHA ≥III, advanced age, diabetes mellitus, left ventricular ejection fraction ≤25% and a history of smoking were significant independent predictors of death without appropriate ICD therapy. 5-year cumulative incidence for death without prior appropriate therapy ranged from 10% (95% CI 6% to 16%) in low-risk patients to 41% (95% CI 33% to 51%) in high-risk patients. CONCLUSIONS: The risk of death without prior appropriate ICD therapy can be predicted in primary prevention ICD patients with ischaemic heart disease, which facilitates patient-tailored risk estimation.
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