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  • Title: Radiochromatography in pharmaceutical and biomedical analysis.
    Author: Veltkamp AC.
    Journal: J Chromatogr; 1990 Oct 12; 531():101-29. PubMed ID: 2258416.
    Abstract:
    Recent advances in the chromatographic analysis of radiolabelled compounds are discussed, with emphasis on the optimization of radioactivity detection in modern chromatographic techniques. Applications are mentioned only infrequently. The state-of-the-art of common radioactivity detection methods is reviewed, as well as promising new detection principles. The latter include flow-through liquid scintillation counting of reversed-phase column eluates based on post-column extraction and solvent segmentation, flow-through heterogeneous counting using a flow cell constructed from axially aligned scintillation fibres, flow cells especially constructed for the detection of beta-emitting radioisotopes in capillary zone electrophoresis, position-sensitive analysers employed in radio planar chromatography and, finally 14C atom counting (as opposed to 14C decay counting) by accelerator mass spectrometry.
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