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  • Title: Calcitonin secretion rate in elderly normal subjects.
    Author: Pedrazzoni M, Ciotti G, Davoli L, Pioli G, Girasole G, Santini T, Michelini M, Vescovi PP, Passeri M.
    Journal: J Endocrinol Invest; 1990 Jun; 13(6):501-5. PubMed ID: 2258578.
    Abstract:
    The aim of the study was to investigate the metabolic clearance rate (MCR) and the secretion rate (SR) of calcitonin (CT) in elderly men and women (mean age +/- SE: 75 +/- 3 and 78 +/- 3 yr, respectively). The basal levels of CT were higher in men than in women (9.6 +/- 3.2 vs 6.0 +/- 1.5 pg/ml; p less than 0.05). The MCR was not significantly different between sexes (905 +/- 54.2 vs 810 +/- 165.1 l/day). In contrast, CT SR was significantly higher in male subjects compared to women (8.7 +/- 3.1 vs 4.8 +/- 1.5 micrograms/day; p less than 0.05). These findings suggest that only a few units of CT are secreted daily by elderly subjects and that the lower basal values of the hormone in women are probably the result of a lower production rate.
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