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  • Title: Chalcone-derived Diels-Alder adducts as NF-κB inhibitors from Morus alba.
    Author: Phung TX, Tran TH, Dan TT, Chau VM, Hoang TH, Nguyen TD.
    Journal: J Asian Nat Prod Res; 2012; 14(6):596-600. PubMed ID: 22587800.
    Abstract:
    A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels-Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC₅₀ values of 4.65 and 7.38 μM, respectively.
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