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  • Title: Crystallization of the Fab from a human monoclonal antibody against gp 41 of human immunodeficiency virus type I.
    Author: Casale E, Wenisch E, He XM, Righetti PG, Snyder RS, Jungbauer A, Tauer C, Ruker F, Carter DC.
    Journal: J Mol Biol; 1990 Dec 05; 216(3):511-2. PubMed ID: 2258926.
    Abstract:
    A monoclonal IgG antibody directed against gp 41 from the human immunodeficiency virus (HIV-1) has been crystallized in both intact and Fab forms. Crystals of the intact antibody grow as tetragonal-like prisms too small for conventional X-ray analysis. However, the Fab portion of the antibody produces suitable plate-like crystals which belong to the space group P2(1)2(1)2(1) with unit cell constants of a = 66.5 A, b = 74.3 A and c = 105.3 A. There is one molecule of Fab in the asymmetric unit. The Fab crystals show diffraction to d-spacings less than 3.0 A.
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