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  • Title: Copper(I)-catalyzed synthesis of 2,5-disubstituted furans and thiophenes from haloalkynes or 1,3-diynes.
    Author: Jiang H, Zeng W, Li Y, Wu W, Huang L, Fu W.
    Journal: J Org Chem; 2012 Jun 01; 77(11):5179-83. PubMed ID: 22590973.
    Abstract:
    A regioselective synthesis of 2,5-disubstituted furans using copper(I) catalyst from haloalkynes in a one-pot procedure has been reported. This chemistry proceeds through the hydration reaction of 1,3-diynes, which can be readily prepared from the coupling reaction of haloalkynes in the presence of CuI. The procedure also can be used for the facile synthesis of 2,5-disubstituted thiophenes.
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