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  • Title: MASP interactions with plasma-derived MBL.
    Author: Laursen IA, Thielens NM, Christiansen M, Houen G.
    Journal: Mol Immunol; 2012 Sep; 52(2):79-87. PubMed ID: 22607836.
    Abstract:
    The interaction of mannan-binding lectin (MBL) with its associated serine proteases (MASPs) was investigated using recombinant (r) MBL, plasma-derived (pd) MBL, rMASP-3 and rMAp19. When mixed with MBL-deficient serum, rMBL and pdMBL associated with free MASP-2 to (re)gain complement-activating activity. MASPs already associated with pdMBL did not exchange with rMASP-3 or rMAp19, which bound to non-overlapping sites on MBL. Thus, rMASP-3 and rMAp19 bound to free available sites on rMBL and pdMBL. These results have important implications for the therapeutic use of MBL preparations.
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